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personpersonLisa YelleLisa YelleFormer toxicology scientist at the Massachusetts State Police Crime Laboratory who now works in biotechnology.← All People
Expert witness

Lisa Yelle

Courtroom still of Lisa Yelle.

Former toxicology scientist at the Massachusetts State Police Crime Laboratory who now works in biotechnology.

44 lines·3 proceedings·2 mentions

About

Lisa Yelle testified for the Commonwealth on Day 6 about general unknown drug screens she performed on blood and urine in the State Police Crime Lab's Toxicology Unit. She said the screens detected the same substances in both samples but could identify only their presence, not their concentrations. After using Exhibit 183 to refresh her memory, she identified trazodone and quetiapine and confirmed a quetiapine metabolite.

Yelle described a syringe malfunction during testing and said it did not affect the results. She also distinguished her testing work from the reporting analyst's responsibilities, identifying Nicholas Roberts as the reporting analyst. Although she agreed that other laboratories could potentially measure concentrations, she did not know whether samples in this case had been sent elsewhere.

Questions about parent drugs and metabolites developed across her examination. During direct examination, Yelle did not adopt counsel's proposed numerical inference about how many drugs had been consumed. On cross-examination, she agreed that a metabolite is a breakdown product of the same drug and does not necessarily represent another drug consumed. After Reddington stated that the defense stipulated to the blood evidence, chain of custody, and testing, she confirmed that the blood test was good. The Commonwealth asked no further questions, and she was excused.

Trial Record (3)

2026 Trial2026 Criminal TrialJul 27, 2026 – Sep 4, 2026Called by prosecution

Lisa Yelle testified on Day 6 that her blood and urine drug screens identified substances but could not measure their concentrations. On cross-examination, she clarified that detecting a drug and its metabolite did not necessarily mean separate drugs had been consumed.

Day 6

DirectDirect Examination - Lisa YelleLisa YelleShanan Buckingham3highlightsMentioned38lines spoken

Summary

Yelle described blood and urine drug detections, stressed that screening could not measure concentrations, and said a syringe malfunction did not affect results.

Mentioned in this proceeding.

Highlights (3)

Quoteβ€œThe general unknown screen is not a quantifiable test. It's just an identification screen. So you wouldn't be able to attribute a specific level of the drug, but just the identification that it was present or not.”— Lisa YelleDefines the central limitation of the screening results: detection does not establish concentration.Open in transcript →Watch this moment ▶
testimony highlightYelle described a syringe malfunction during the batch run, explained replacement and restart procedures using a control, and said the malfunction did not affect the results.Open in transcript →Watch this moment ▶